Diagnostic metabolite biomarkers of chronic typhoid carriage
نویسندگان
چکیده
منابع مشابه
Diagnostic metabolite biomarkers of chronic typhoid carriage
BACKGROUND Salmonella Typhi and Salmonella Paratyphi A are the agents of enteric (typhoid) fever; both can establish chronic carriage in the gallbladder. Chronic Salmonella carriers are typically asymptomatic, intermittently shedding bacteria in the feces, and contributing to disease transmission. Detecting chronic carriers is of public health relevance in areas where enteric fever is endemic, ...
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Typhoid is a systemic bacterial disease caused by Salmonella enterica subspecies enterica serovar Typhi (commonly S. Typhi).1 It is usually contracted by ingestion of food or water contaminated by faecal or urinary carriers excreting S. Typhi.2 Typhoid continues to contribute to the global burden of disease, particularly in countries with low and middle gross national income.1 Locally acquired ...
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Current serological diagnostic assays for typhoid fever are based on detecting antibodies against Salmonella LPS or flagellum, resulting in a high false-positive rate. Here we used a protein microarray containing 2,724 Salmonella enterica serovar Typhi antigens (>63% of proteome) and identified antibodies against 16 IgG antigens and 77 IgM antigens that were differentially reactive among acute ...
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" A, a saturated solution of sulphanilic acid in dilute (1 in 20) hydrochloric acid; B, a ?5 per cent, solution of sodic nitrite in distilled water. (Both of these solutions must be fresh?especially the latter, which cannot be depended on for more than a week at the longest. When they are mixed, of course, a solution of sulphanilic acid containing free nitrous acid is produced, which is the act...
متن کاملSearching for the elusive typhoid diagnostic
Typhoid (enteric) fever is still a common disease in many developing countries but current diagnostic tests are inadequate. Studies on pathogenesis and genomics have provided new insight into the organisms that cause enteric fever. Better understanding of the microorganisms explains, in part, why our current typhoid methodologies are limited in their diagnostic information and why developing ne...
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ژورنال
عنوان ژورنال: PLOS Neglected Tropical Diseases
سال: 2018
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0006215